Empowering Precision Diagnostics
Bringing ImmunoGuide ELISA technologies to Europe and beyond
Validated ELISA kits for therapeutic drug monitoring and anti-drug antibody detection, for clinical labs, research institutions, and biotech teams. For Research Use Only.
Featured ELISA kits
Drug-level and anti-drug antibody assays across TNF-alpha, VEGF, EGFR, HER2, and more.
ADALIMUMAB ELISA
Analyte: Adalimumab
View kitADALIMUMAB ELISA (MAB-BASED)
Analyte: Adalimumab
View kitAFLIBERCEPT ELISA
Analyte: Aflibercept
View kitANTIBODY TO ADALIMUMAB ELISA
Analyte: Adalimumab
View kitANTIBODY TO BEVACIZUMAB ELISA
Analyte: Bevacizumab
View kitANTIBODY TO CERTOLIZUMAB PEGOL ELISA
Analyte: Certolizumab Pegol
View kitFrom our journal
Background on ELISA methods, therapeutic drug monitoring, anti-drug antibodies, and assay validation.
When ADA Titer Is Not Enough: Rethinking the Gate to Neutralizing Antibody Testing
A series of papers published in Bioanalysis throughout 2026 argues that titer-gated neutralizing antibody testing can miss clinically relevant neutralization while generating incidence numbers that mislead development teams. The papers converge on signal-to-noise ratio from the screening tier as a continuous, biologically richer alternative to discretized titer scores, and call for NAb assay sensitivity to be matched to molecule-specific clinical endpoints rather than population-average tier thresholds.
Multiplex Luminex Assay Enables Simultaneous Domain-Specific ADA Detection for Multidomain Biotherapeutics
Standard bridging immunogenicity assays cannot distinguish which domain of a multidomain biotherapeutic is driving an anti-drug antibody response. A Luminex bead-based multiplex approach published in Bioanalysis in November 2026 addresses this gap by enabling simultaneous, domain-resolved ADA detection within a single assay well, with sub-100 ng/mL sensitivity and no prozone effects up to 20,000 ng/mL. This article reviews the method, its validation considerations, and what it means for scientists building immunogenicity programs for bispecific antibodies and other multidomain drugs.
Pembrolizumab Biosimilars Are Entering Clinical Review: What the PK-Only Pathway Means for Immunogenicity Assay Scientists
The FDA accepted the first publicly announced pembrolizumab biosimilar BLA for review in October 2026, using a pharmacokinetic-only pivotal strategy that skips a comparative Phase 3 efficacy trial. For immunogenicity assay scientists, this regulatory pivot reframes how ADA comparability must be designed, validated, and interpreted in a drug class with low but clinically consequential reference product immunogenicity.